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Symbol
Name
ID 		Crebbp
CREB binding protein
MGI:1098280
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Agenesis of corpus callosum
Hyperintensity of cerebral white matter on MRI
Spina bifida
Spina bifida occulta
Incoordination
Poor coordination
EEG abnormality
Delayed speech and language development
Irritability
Anxiety
Autistic behavior
Autism
Hyperactivity
Attention deficit hyperactivity disorder
Impulsivity
Self-mutilation
Phonophobia
Short attention span
Intellectual disability
Intellectual disability, mild
Sleep abnormality
Obstructive sleep apnea
Hyperreflexia
Unsteady gait
Global developmental delay
Delayed gross motor development
Seizure
Disease(s) Associated with CREBBP
Rubinstein-Taybi syndrome

Mouse Phenotypes
nervous system phenotype
seizures
intracranial hemorrhage
abnormal neural tube morphology
incomplete rostral neuropore closure
open neural tube
abnormal nervous system morphology
abnormal forebrain morphology
exencephaly
abnormal spinal cord morphology
reduced long-term potentiation
increased post-tetanic potentiation
Availability Mouse Genotype
CrebbpGt(U-San)112Imeg/CrebbpGt(U-San)112Imeg
Crebbptm1Dli/Crebbptm1Dli
Crebbptm1Sis/Crebbptm1Sis
Crebbptm2Pkb/Crebbptm2Pkb
CrebbpGt(U-San)112Imeg/Crebbp+ *
Crebbptm1.1Ltz/Crebbp+
Tg(Camk2a-Crebbp*)1364Tabe/0
Crebbptm1.2Ltz/Crebbptm1.2Ltz
Tg(Camk2a-cre)T29-1Stl/0  (conditional)		 *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory